Gliotransmission by Prostaglandin E2: a prerequisite for GnRH neuronal function?
Over the past four decades it has become clear that prostaglandin E2 (PGE2), a phospholipid-derived signaling molecule, plays a fundamental role in modulating the GnRH neuroendocrine system and in shaping the hypothalamus.In this review, after a brief historical overview, we highlight studies revealing that PGE2 released by glial cells such as astr